Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Identifieur interne : 002C33 ( Main/Exploration ); précédent : 002C32; suivant : 002C34Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Auteurs : Alireza Moayyeri [Royaume-Uni] ; Yi-Hsiang Hsu [États-Unis] ; David Karasik [États-Unis] ; Karol Estrada [Pays-Bas, États-Unis] ; Su-Mei Xiao ; Carrie Nielson ; Priya Srikanth ; Sylvie Giroux [Canada] ; Scott G. Wilson [Royaume-Uni, Australie] ; Hou-Feng Zheng [Canada] ; Albert V. Smith [Islande] ; Stephen R. Pye ; Paul J. Leo [Australie] ; Alexander Teumer ; Joo-Yeon Hwang [Corée du Sud] ; Claes Ohlsson [Suède] ; Fiona Mcguigan ; Ryan L. Minster ; Caroline Hayward [Royaume-Uni] ; José M. Olmos [Espagne] ; Leo-Pekka Lyytik Inen [Finlande] ; Joshua R. Lewis [Australie] ; Karin M. A. Swart ; Laura Masi ; Chris Oldmeadow [Australie] ; Elizabeth G. Holliday [Australie] ; Sulin Cheng [Finlande] ; Natasja M. Van Schoor ; Nicholas C. Harvey [Royaume-Uni] ; Marcin Kruk [Pologne] ; Fabiola Del Greco M [Allemagne] ; Wilmar Igl ; Olivia Trummer [Autriche] ; Efi Grigoriou [Grèce] ; Robert Luben [Royaume-Uni] ; Ching-Ti Liu [États-Unis] ; Yanhua Zhou [États-Unis] ; Ling Oei [Pays-Bas] ; Carolina Medina-Gomez [Pays-Bas] ; Joseph Zmuda [États-Unis] ; Greg Tranah [États-Unis] ; Suzanne J. Brown [Australie] ; Frances M. Williams [Royaume-Uni] ; Nicole Soranzo [Royaume-Uni] ; Johanna Jakobsdottir [Islande] ; Kristin Siggeirsdottir [Islande] ; Kate L. Holliday ; Anke Hannemann ; Min Jin Go [Corée du Sud] ; Melissa Garcia [États-Unis] ; Ozren Polasek [Croatie] ; Marika Laaksonen [Finlande] ; Kun Zhu [Australie] ; Anke W. Enneman ; Mark Mcevoy [Australie] ; Roseanne Peel [Australie] ; Pak Chung Sham [République populaire de Chine] ; Maciej Jaworski [Pologne] ; Sa Johansson ; Andrew A. Hicks [Allemagne] ; Pawel Pludowski [Pologne] ; Rodney Scott [Australie] ; Rosalie A. M. Dhonukshe-Rutten [Pays-Bas] ; Nathalie Van Der Velde [Pays-Bas] ; Mika K Hönen [Finlande] ; Jorma S. Viikari ; Harri Siev Nen [Finlande] ; Olli T. Raitakari [Finlande] ; Jesús González-Macías [Espagne] ; Jose L. Hernández [Espagne] ; Dan Mellström [Suède] ; Östen Ljunggren [Suède] ; Yoon Shin Cho [Corée du Sud] ; Uwe Völker ; Matthias Nauck ; Georg Homuth ; Henry Völzke [Allemagne] ; Robin Haring ; Matthew A. Brown [Australie] ; Eugene Mccloskey [Royaume-Uni] ; Geoffrey C. Nicholson [Australie] ; Richard Eastell [Royaume-Uni] ; John A. Eisman [Australie] ; Graeme Jones [Australie] ; Ian R. Reid [Nouvelle-Zélande] ; Elaine M. Dennison [Royaume-Uni] ; John Wark [Australie] ; Steven Boonen ; Dirk Vanderschueren [Belgique] ; Frederick C. W. Wu [Royaume-Uni] ; Thor Aspelund [Islande] ; J. Brent Richards [Royaume-Uni, Canada] ; Doug Bauer [États-Unis] ; Albert Hofman [Pays-Bas] ; Kay-Tee Khaw [Royaume-Uni] ; George Dedoussis [Grèce] ; Barbara Obermayer-Pietsch [Autriche] ; Ulf Gyllensten ; Peter P. Pramstaller [Allemagne] ; Roman S. Lorenc [Pologne] ; Cyrus Cooper [Royaume-Uni] ; Annie Wai Chee Kung ; Paul Lips [Pays-Bas] ; Markku Alen [Finlande] ; John Attia [Australie] ; Maria Luisa Brandi [Italie] ; Lisette C. P. G. M. De Groot [Pays-Bas] ; Terho Lehtim Ki [Finlande] ; José A. Riancho [Espagne] ; Harry Campbell [Royaume-Uni] ; Yongmei Liu [États-Unis] ; Tamara B. Harris [États-Unis] ; Kristina Akesson ; Magnus Karlsson [Suède] ; Jong-Young Lee [Corée du Sud] ; Henri Wallaschofski ; Emma L. Duncan [Australie] ; Terence W. O'Neill ; Vilmundur Gudnason [Islande] ; Timothy D. Spector [Royaume-Uni] ; François Rousseau [Canada] ; Eric Orwoll [États-Unis] ; Steven R. Cummings [États-Unis] ; Nick J. Wareham [Royaume-Uni] ; Fernando Rivadeneira [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Richard L. Prince [Australie] ; Douglas P. Kiel [États-Unis] ; Jonathan Reeve [Royaume-Uni] ; Stephen K. Kaptoge [Royaume-Uni]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2014.
Abstract
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA;
Url:
DOI: 10.1093/hmg/ddt675
PubMed: 24430505
PubMed Central: 4038791
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, Corée du Sud, Croatie, Espagne, Finlande, Grèce, Islande, Italie, Nouvelle-Zélande, Pays-Bas, Pologne, Royaume-Uni, République populaire de Chine, Suède, États-Unis
- Massachusetts
- Boston
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see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institute for Aging Research</addr-line>,<institution>Hebrew SeniorLife</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Medicine</addr-line>,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" 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Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="af7"><addr-line>Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Program in Medical and 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Aging</addr-line></nlm:aff><wicri:noCountry code="subfield">Hormone & Healthy Aging</wicri:noCountry></affiliation></author><author><name sortKey="Nielson, Carrie" sort="Nielson, Carrie" uniqKey="Nielson C" first="Carrie" last="Nielson">Carrie Nielson</name><affiliation><nlm:aff wicri:cut=" and" id="af14"><addr-line>Department of Public Health & Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Srikanth, Priya" sort="Srikanth, Priya" uniqKey="Srikanth P" first="Priya" last="Srikanth">Priya Srikanth</name><affiliation><nlm:aff wicri:cut=" and" id="af14"><addr-line>Department of Public Health & Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Giroux, Sylvie" sort="Giroux, Sylvie" uniqKey="Giroux S" first="Sylvie" last="Giroux">Sylvie Giroux</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>Centre de Récherche du CHU de Québec/HSFA</institution>,<addr-line>Québec City</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Scott G" sort="Wilson, Scott G" uniqKey="Wilson S" first="Scott G." last="Wilson">Scott G. Wilson</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Hou Feng" sort="Zheng, Hou Feng" uniqKey="Zheng H" first="Hou-Feng" last="Zheng">Hou-Feng Zheng</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Departments of Medicine, Human Genetics, Epidemiology and Biostatistics</addr-line>,<institution>Lady Davis Institute</institution>,<institution>McGill University</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pye, Stephen R" sort="Pye, Stephen R" uniqKey="Pye S" first="Stephen R." last="Pye">Stephen R. Pye</name><affiliation><nlm:aff wicri:cut=", and" id="af22"><addr-line>Arthritis Research UK Epidemiology Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J." last="Leo">Paul J. Leo</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Human Genetics Group</addr-line>,<institution>University of Queensland Diamantina Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="af25"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hwang, Joo Yeon" sort="Hwang, Joo Yeon" uniqKey="Hwang J" first="Joo-Yeon" last="Hwang">Joo-Yeon Hwang</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Center for Genome Science</addr-line>,<institution>National Institute of Health, Osong Health Technology Administration Complex</institution>,<addr-line>Chungcheongbuk-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Centre for Bone and Arthritis Research, Institute of Medicine</addr-line>,<institution>Sahlgrenska Academy, University of Gothenburg</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguigan, Fiona" sort="Mcguigan, Fiona" uniqKey="Mcguigan F" first="Fiona" last="Mcguigan">Fiona Mcguigan</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences</addr-line></nlm:aff><wicri:noCountry code="subfield">Department of Clinical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><affiliation><nlm:aff wicri:cut=" and" id="af32"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit</addr-line>,<institution>University of Edinburgh</institution>,<addr-line>Edinburgh</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olmos, Jose M" sort="Olmos, Jose M" uniqKey="Olmos J" first="José M." last="Olmos">José M. Olmos</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af38"><addr-line>Department of Clinical Chemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lewis, Joshua R" sort="Lewis, Joshua R" uniqKey="Lewis J" first="Joshua R." last="Lewis">Joshua R. Lewis</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Swart, Karin M A" sort="Swart, Karin M A" uniqKey="Swart K" first="Karin M. A." last="Swart">Karin M. A. Swart</name><affiliation><nlm:aff id="af40"><addr-line>Department of Epidemiology and Biostatistics, the EMGO Institute of Health and Care Research</addr-line></nlm:aff><wicri:noCountry code="subfield">the EMGO Institute of Health and Care Research</wicri:noCountry></affiliation></author><author><name sortKey="Masi, Laura" sort="Masi, Laura" uniqKey="Masi L" first="Laura" last="Masi">Laura Masi</name><affiliation><nlm:aff wicri:cut=" and" id="af43"><addr-line>Metabolic Bone Diseases Unit – AOUC</addr-line></nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Chris" sort="Oldmeadow, Chris" uniqKey="Oldmeadow C" first="Chris" last="Oldmeadow">Chris Oldmeadow</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Sulin" sort="Cheng, Sulin" uniqKey="Cheng S" first="Sulin" last="Cheng">Sulin Cheng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>Department of Health Sciences</addr-line>,<institution>University of Jyväskylä</institution>,<addr-line>Jyväskylä</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Schoor, Natasja M" sort="Van Schoor, Natasja M" uniqKey="Van Schoor N" first="Natasja M." last="Van Schoor">Natasja M. Van Schoor</name><affiliation><nlm:aff id="af40"><addr-line>Department of Epidemiology and Biostatistics, the EMGO Institute of Health and Care Research</addr-line></nlm:aff><wicri:noCountry code="subfield">the EMGO Institute of Health and Care Research</wicri:noCountry></affiliation></author><author><name sortKey="Harvey, Nicholas C" sort="Harvey, Nicholas C" uniqKey="Harvey N" first="Nicholas C." last="Harvey">Nicholas C. Harvey</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kruk, Marcin" sort="Kruk, Marcin" uniqKey="Kruk M" first="Marcin" last="Kruk">Marcin Kruk</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Del Greco M, Fabiola" sort="Del Greco M, Fabiola" uniqKey="Del Greco M F" first="Fabiola" last="Del Greco M">Fabiola Del Greco M</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Center for Biomedicine</addr-line>,<institution>European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff wicri:cut=" and" id="af50"><addr-line>Department of Immunology, Genetics and Pathology, SciLifeLab</addr-line>,<institution>Rudbeck Laboratory</institution></nlm:aff></affiliation></author><author><name sortKey="Trummer, Olivia" sort="Trummer, Olivia" uniqKey="Trummer O" first="Olivia" last="Trummer">Olivia Trummer</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Internal Medicine, Division of Endocrinology and Metabolism</addr-line>,<institution>Medical University Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grigoriou, Efi" sort="Grigoriou, Efi" uniqKey="Grigoriou E" first="Efi" last="Grigoriou">Efi Grigoriou</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Department of Nutrition and Dietetics</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Yanhua" sort="Zhou, Yanhua" uniqKey="Zhou Y" first="Yanhua" last="Zhou">Yanhua Zhou</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oei, Ling" sort="Oei, Ling" uniqKey="Oei L" first="Ling" last="Oei">Ling Oei</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zmuda, Joseph" sort="Zmuda, Joseph" uniqKey="Zmuda J" first="Joseph" last="Zmuda">Joseph Zmuda</name><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Department of Epidemiology, Graduate School of Public Health</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pitsburgh, PA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tranah, Greg" sort="Tranah, Greg" uniqKey="Tranah G" first="Greg" last="Tranah">Greg Tranah</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>San Francisco Coordinating Center, California Pacific Medical Center Research Institute</addr-line></nlm:aff><wicri:noCountry code="subfield">California Pacific Medical Center Research Institute</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Suzanne J" sort="Brown, Suzanne J" uniqKey="Brown S" first="Suzanne J." last="Brown">Suzanne J. Brown</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Frances M" sort="Williams, Frances M" uniqKey="Williams F" first="Frances M." last="Williams">Frances M. Williams</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="af57"><institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jakobsdottir, Johanna" sort="Jakobsdottir, Johanna" uniqKey="Jakobsdottir J" first="Johanna" last="Jakobsdottir">Johanna Jakobsdottir</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siggeirsdottir, Kristin" sort="Siggeirsdottir, Kristin" uniqKey="Siggeirsdottir K" first="Kristin" last="Siggeirsdottir">Kristin Siggeirsdottir</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Kate L" sort="Holliday, Kate L" uniqKey="Holliday K" first="Kate L." last="Holliday">Kate L. Holliday</name><affiliation><nlm:aff wicri:cut=", and" id="af22"><addr-line>Arthritis Research UK Epidemiology Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hannemann, Anke" sort="Hannemann, Anke" uniqKey="Hannemann A" first="Anke" last="Hannemann">Anke Hannemann</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Go, Min Jin" sort="Go, Min Jin" uniqKey="Go M" first="Min Jin" last="Go">Min Jin Go</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Center for Genome Science</addr-line>,<institution>National Institute of Health, Osong Health Technology Administration Complex</institution>,<addr-line>Chungcheongbuk-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Public Health, Medical School</addr-line>,<institution>University of Split</institution>,<addr-line>Split</addr-line>,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laaksonen, Marika" sort="Laaksonen, Marika" uniqKey="Laaksonen M" first="Marika" last="Laaksonen">Marika Laaksonen</name><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Department of Food and Environmental Sciences</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Kun" sort="Zhu, Kun" uniqKey="Zhu K" first="Kun" last="Zhu">Kun Zhu</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enneman, Anke W" sort="Enneman, Anke W" uniqKey="Enneman A" first="Anke W." last="Enneman">Anke W. Enneman</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcevoy, Mark" sort="Mcevoy, Mark" uniqKey="Mcevoy M" first="Mark" last="Mcevoy">Mark Mcevoy</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peel, Roseanne" sort="Peel, Roseanne" uniqKey="Peel R" first="Roseanne" last="Peel">Roseanne Peel</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sham, Pak Chung" sort="Sham, Pak Chung" uniqKey="Sham P" first="Pak Chung" last="Sham">Pak Chung Sham</name><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Department of Psychiatry</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Centre for Reproduction, Development and Growth</addr-line>,<institution>The University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jaworski, Maciej" sort="Jaworski, Maciej" uniqKey="Jaworski M" first="Maciej" last="Jaworski">Maciej Jaworski</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff wicri:cut=" and" id="af50"><addr-line>Department of Immunology, Genetics and Pathology, SciLifeLab</addr-line>,<institution>Rudbeck Laboratory</institution></nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Center for Biomedicine</addr-line>,<institution>European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pludowski, Pawel" sort="Pludowski, Pawel" uniqKey="Pludowski P" first="Pawel" last="Pludowski">Pawel Pludowski</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dhonukshe Rutten, Rosalie A M" sort="Dhonukshe Rutten, Rosalie A M" uniqKey="Dhonukshe Rutten R" first="Rosalie A. M." last="Dhonukshe-Rutten">Rosalie A. M. Dhonukshe-Rutten</name><affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Human Nutrition</addr-line>,<institution>Wageningen University</institution>,<addr-line>Wageningen</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Velde, Nathalie" sort="Van Der Velde, Nathalie" uniqKey="Van Der Velde N" first="Nathalie" last="Van Der Velde">Nathalie Van Der Velde</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Department of Internal Medicine, Section of Geriatrics</addr-line>,<institution>Academic Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>Department of Clinical Physiology</addr-line>,<institution>University of Tampere School of Medicine</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Department of Clinical Physiology</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viikari, Jorma S" sort="Viikari, Jorma S" uniqKey="Viikari J" first="Jorma S." last="Viikari">Jorma S. Viikari</name><affiliation><nlm:aff wicri:cut=" and" id="af64"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af66"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Siev Nen, Harri" sort="Siev Nen, Harri" uniqKey="Siev Nen H" first="Harri" last="Siev Nen">Harri Siev Nen</name><affiliation wicri:level="1"><nlm:aff id="af68"><institution>The UKK Institute for Health Promotion Research</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="1"><nlm:aff id="af65"><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,<institution>Turku University Hospital</institution>,<addr-line>Turku</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af67"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,<institution>University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Macias, Jesus" sort="Gonzalez Macias, Jesus" uniqKey="Gonzalez Macias J" first="Jesús" last="González-Macías">Jesús González-Macías</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hernandez, Jose L" sort="Hernandez, Jose L" uniqKey="Hernandez J" first="Jose L." last="Hernández">Jose L. Hernández</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mellstrom, Dan" sort="Mellstrom, Dan" uniqKey="Mellstrom D" first="Dan" last="Mellström">Dan Mellström</name><affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Centre for Bone and Arthritis Research, Institute of Medicine</addr-line>,<institution>Sahlgrenska Academy, University of Gothenburg</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ljunggren, Osten" sort="Ljunggren, Osten" uniqKey="Ljunggren O" first="Östen" last="Ljunggren">Östen Ljunggren</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Department of Medical Sciences</addr-line>,<institution>University of Uppsala</institution>,<addr-line>Uppsala</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cho, Yoon Shin" sort="Cho, Yoon Shin" uniqKey="Cho Y" first="Yoon Shin" last="Cho">Yoon Shin Cho</name><affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>Department of Biomedical Science</addr-line>,<institution>Hallym University</institution>,<addr-line>Chuncheon, Gangwon-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="af25"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="af25"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>Institute for Community Medicine</addr-line>,<institution>University Medicine Greifswald</institution>,<institution>University of Greifswald</institution>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haring, Robin" sort="Haring, Robin" uniqKey="Haring R" first="Robin" last="Haring">Robin Haring</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A." last="Brown">Matthew A. Brown</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Human Genetics Group</addr-line>,<institution>University of Queensland Diamantina Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mccloskey, Eugene" sort="Mccloskey, Eugene" uniqKey="Mccloskey E" first="Eugene" last="Mccloskey">Eugene Mccloskey</name><affiliation><nlm:aff wicri:cut=" and" id="af70"><addr-line>National Institute for Health and Research (NIHR) Musculoskeletal Biomedical Research Unit</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af71"><addr-line>Academic Unit of Bone Metabolism</addr-line>,<institution>Metabolic Bone Centre</institution>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nicholson, Geoffrey C" sort="Nicholson, Geoffrey C" uniqKey="Nicholson G" first="Geoffrey C." last="Nicholson">Geoffrey C. Nicholson</name><affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Rural Clinical School</addr-line>,<institution>The University of Queensland</institution>,<addr-line>Toowoomba</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eastell, Richard" sort="Eastell, Richard" uniqKey="Eastell R" first="Richard" last="Eastell">Richard Eastell</name><affiliation wicri:level="1"><nlm:aff id="af71"><addr-line>Academic Unit of Bone Metabolism</addr-line>,<institution>Metabolic Bone Centre</institution>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eisman, John A" sort="Eisman, John A" uniqKey="Eisman J" first="John A." last="Eisman">John A. Eisman</name><affiliation wicri:level="1"><nlm:aff id="af73"><addr-line>Clinical Translation and Advanced Education and Osteoporosis and Bone Biology Program</addr-line>,<institution>Garvan Institute of Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Department of Medicine</addr-line>,<institution>University of New South Wales</institution>,<addr-line>Kensington</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Clinical Excellence and Research, School of Medicine Sydney</addr-line>,<institution>University of Notre Dame</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Department of Endocrinology</addr-line>,<institution>St Vincent's Hospital</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Graeme" sort="Jones, Graeme" uniqKey="Jones G" first="Graeme" last="Jones">Graeme Jones</name><affiliation wicri:level="1"><nlm:aff id="af77"><institution>Menzies Research Institute</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reid, Ian R" sort="Reid, Ian R" uniqKey="Reid I" first="Ian R." last="Reid">Ian R. Reid</name><affiliation wicri:level="1"><nlm:aff id="af78"><addr-line>Department of Medicine</addr-line>,<institution>University of Auckland</institution>,<addr-line>Auckland</addr-line>,<country>New Zealand</country></nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dennison, Elaine M" sort="Dennison, Elaine M" uniqKey="Dennison E" first="Elaine M." last="Dennison">Elaine M. Dennison</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wark, John" sort="Wark, John" uniqKey="Wark J" first="John" last="Wark">John Wark</name><affiliation wicri:level="1"><nlm:aff id="af79"><addr-line>Department of Clinical Sciences</addr-line>,<institution>Royal Melbourne Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><nlm:aff wicri:cut=" and" id="af80"><addr-line>Leuven University Division of Geriatric Medicine and Centre for Metabolic Bone Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vanderschueren, Dirk" sort="Vanderschueren, Dirk" uniqKey="Vanderschueren D" first="Dirk" last="Vanderschueren">Dirk Vanderschueren</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Department of Andrology and Endocrinology</addr-line>,<institution>Katholieke Universiteit Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Frederick C W" sort="Wu, Frederick C W" uniqKey="Wu F" first="Frederick C. W." last="Wu">Frederick C. W. Wu</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Andrology Research Unit, Developmental & Regenerative Biomedicine Research Group</addr-line>,<institution>The University of Manchester</institution>,<institution>Manchester Academic Health Science Centre, Manchester Royal Infirmary</institution>,<addr-line>Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, J Brent" sort="Richards, J Brent" uniqKey="Richards J" first="J. Brent" last="Richards">J. Brent Richards</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Departments of Medicine, Human Genetics, Epidemiology and Biostatistics</addr-line>,<institution>Lady Davis Institute</institution>,<institution>McGill University</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bauer, Doug" sort="Bauer, Doug" uniqKey="Bauer D" first="Doug" last="Bauer">Doug Bauer</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>San Francisco Coordinating Center, California Pacific Medical Center Research Institute</addr-line></nlm:aff><wicri:noCountry code="subfield">California Pacific Medical Center Research Institute</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Department of Nutrition and Dietetics</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Obermayer Pietsch, Barbara" sort="Obermayer Pietsch, Barbara" uniqKey="Obermayer Pietsch B" first="Barbara" last="Obermayer-Pietsch">Barbara Obermayer-Pietsch</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Internal Medicine, Division of Endocrinology and Metabolism</addr-line>,<institution>Medical University Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff wicri:cut=" and" id="af50"><addr-line>Department of Immunology, Genetics and Pathology, SciLifeLab</addr-line>,<institution>Rudbeck Laboratory</institution></nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Center for Biomedicine</addr-line>,<institution>European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lorenc, Roman S" sort="Lorenc, Roman S" uniqKey="Lorenc R" first="Roman S." last="Lorenc">Roman S. Lorenc</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>NIHR Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Science</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kung, Annie Wai Chee" sort="Kung, Annie Wai Chee" uniqKey="Kung A" first="Annie Wai Chee" last="Kung">Annie Wai Chee Kung</name><affiliation><nlm:aff id="af10"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Research Centre of Heart, Brain, Hormone & Healthy Aging</addr-line></nlm:aff><wicri:noCountry code="subfield">Hormone & Healthy Aging</wicri:noCountry></affiliation></author><author><name sortKey="Lips, Paul" sort="Lips, Paul" uniqKey="Lips P" first="Paul" last="Lips">Paul Lips</name><affiliation><nlm:aff wicri:cut=" and" id="af41"><addr-line>Department of Endocrinology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af42"><addr-line>EMGO Institute for Health and Care Research</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alen, Markku" sort="Alen, Markku" uniqKey="Alen M" first="Markku" last="Alen">Markku Alen</name><affiliation wicri:level="1"><nlm:aff id="af83"><addr-line>Department of Medical Rehabilitation</addr-line>,<institution>Oulu University Hospital and Institute of Health Sciences</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name><affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Surgery and Translational Medicine</addr-line>,<institution>University of Florence</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Groot, Lisette C P G M" sort="De Groot, Lisette C P G M" uniqKey="De Groot L" first="Lisette C. P. G. M." last="De Groot">Lisette C. P. G. M. De Groot</name><affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Human Nutrition</addr-line>,<institution>Wageningen University</institution>,<addr-line>Wageningen</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af38"><addr-line>Department of Clinical Chemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Riancho, Jose A" sort="Riancho, Jose A" uniqKey="Riancho J" first="José A." last="Riancho">José A. Riancho</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="af84"><institution>Centre for Population Health Sciences, Medical School</institution>,<addr-line>Teviot Place, Edinburgh</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="af85"><addr-line>Center for Human Genetics, Division of Public Health Sciences</addr-line>,<institution>Wake Forest School of Medicine</institution>,<addr-line>Winston-Salem, NC</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akesson, Kristina" sort="Akesson, Kristina" uniqKey="Akesson K" first="Kristina" last="Akesson">Kristina Akesson</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences</addr-line></nlm:aff><wicri:noCountry code="subfield">Department of Clinical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Karlsson, Magnus" sort="Karlsson, Magnus" uniqKey="Karlsson M" first="Magnus" last="Karlsson">Magnus Karlsson</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences</addr-line></nlm:aff><wicri:noCountry code="subfield">Department of Clinical Sciences</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Orthopaedics</addr-line>,<institution>Lund University</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Jong Young" sort="Lee, Jong Young" uniqKey="Lee J" first="Jong-Young" last="Lee">Jong-Young Lee</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Center for Genome Science</addr-line>,<institution>National Institute of Health, Osong Health Technology Administration Complex</institution>,<addr-line>Chungcheongbuk-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duncan, Emma L" sort="Duncan, Emma L" uniqKey="Duncan E" first="Emma L." last="Duncan">Emma L. Duncan</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Human Genetics Group</addr-line>,<institution>University of Queensland Diamantina Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Endocrinology</addr-line>,<institution>Royal Brisbane and Women's Hospital</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Neill, Terence W" sort="O Neill, Terence W" uniqKey="O Neill T" first="Terence W." last="O'Neill">Terence W. O'Neill</name><affiliation><nlm:aff wicri:cut=", and" id="af22"><addr-line>Arthritis Research UK Epidemiology Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rousseau, Francois" sort="Rousseau, Francois" uniqKey="Rousseau F" first="François" last="Rousseau">François Rousseau</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>Centre de Récherche du CHU de Québec/HSFA</institution>,<addr-line>Québec City</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af87"><addr-line>Department of Molecular Biology, Medical Biochemistry and Pathology</addr-line></nlm:aff><wicri:noCountry code="subfield">Medical Biochemistry and Pathology</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af88"><addr-line>The APOGEE-Net/CanGèneTest Network on Genetic Health Services and Policy</addr-line>,<institution>Université Laval</institution>,<addr-line>Québec City</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Orwoll, Eric" sort="Orwoll, Eric" uniqKey="Orwoll E" first="Eric" last="Orwoll">Eric Orwoll</name><affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>School of Medicine</addr-line>,<institution>Oregon Health & Science University</institution>,<addr-line>Portland, OR</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cummings, Steven R" sort="Cummings, Steven R" uniqKey="Cummings S" first="Steven R." last="Cummings">Steven R. Cummings</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>San Francisco Coordinating Center, California Pacific Medical Center Research Institute</addr-line></nlm:aff><wicri:noCountry code="subfield">California Pacific Medical Center Research Institute</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af89"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>Institute of Metabolic Science</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prince, Richard L" sort="Prince, Richard L" uniqKey="Prince R" first="Richard L." last="Prince">Richard L. Prince</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P." last="Kiel">Douglas P. Kiel</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institute for Aging Research</addr-line>,<institution>Hebrew SeniorLife</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Medicine</addr-line>,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reeve, Jonathan" sort="Reeve, Jonathan" uniqKey="Reeve J" first="Jonathan" last="Reeve">Jonathan Reeve</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>NIHR Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Science</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af90"><institution>Strangeways Research Laboratory</institution>,<addr-line>Worts’ Causeway, Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaptoge, Stephen K" sort="Kaptoge, Stephen K" uniqKey="Kaptoge S" first="Stephen K." last="Kaptoge">Stephen K. Kaptoge</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af90"><institution>Strangeways Research Laboratory</institution>,<addr-line>Worts’ Causeway, Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24430505</idno><idno type="pmc">4038791</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038791</idno><idno type="RBID">PMC:4038791</idno><idno type="doi">10.1093/hmg/ddt675</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000945</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000945</idno><idno type="wicri:Area/Pmc/Curation">000921</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000921</idno><idno type="wicri:Area/Pmc/Checkpoint">001228</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001228</idno><idno type="wicri:Area/Ncbi/Merge">000C39</idno><idno type="wicri:Area/Ncbi/Curation">000C39</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C39</idno><idno type="wicri:doubleKey">0964-6906:2014:Moayyeri A:genetic:determinants:of</idno><idno type="wicri:Area/Main/Merge">002D60</idno><idno type="wicri:Area/Main/Curation">002C33</idno><idno type="wicri:Area/Main/Exploration">002C33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium</title><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institute for Aging Research</addr-line>,<institution>Hebrew SeniorLife</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Medicine</addr-line>,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institute for Aging Research</addr-line>,<institution>Hebrew SeniorLife</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Medicine</addr-line>,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="af7"><addr-line>Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Program in Medical and Population Genetics, Broad Institute, Cambridge, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xiao, Su Mei" sort="Xiao, Su Mei" uniqKey="Xiao S" first="Su-Mei" last="Xiao">Su-Mei Xiao</name><affiliation><nlm:aff id="af10"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Research Centre of Heart, Brain, Hormone & Healthy Aging</addr-line></nlm:aff><wicri:noCountry code="subfield">Hormone & Healthy Aging</wicri:noCountry></affiliation></author><author><name sortKey="Nielson, Carrie" sort="Nielson, Carrie" uniqKey="Nielson C" first="Carrie" last="Nielson">Carrie Nielson</name><affiliation><nlm:aff wicri:cut=" and" id="af14"><addr-line>Department of Public Health & Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Srikanth, Priya" sort="Srikanth, Priya" uniqKey="Srikanth P" first="Priya" last="Srikanth">Priya Srikanth</name><affiliation><nlm:aff wicri:cut=" and" id="af14"><addr-line>Department of Public Health & Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Giroux, Sylvie" sort="Giroux, Sylvie" uniqKey="Giroux S" first="Sylvie" last="Giroux">Sylvie Giroux</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>Centre de Récherche du CHU de Québec/HSFA</institution>,<addr-line>Québec City</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Scott G" sort="Wilson, Scott G" uniqKey="Wilson S" first="Scott G." last="Wilson">Scott G. Wilson</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Hou Feng" sort="Zheng, Hou Feng" uniqKey="Zheng H" first="Hou-Feng" last="Zheng">Hou-Feng Zheng</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Departments of Medicine, Human Genetics, Epidemiology and Biostatistics</addr-line>,<institution>Lady Davis Institute</institution>,<institution>McGill University</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pye, Stephen R" sort="Pye, Stephen R" uniqKey="Pye S" first="Stephen R." last="Pye">Stephen R. Pye</name><affiliation><nlm:aff wicri:cut=", and" id="af22"><addr-line>Arthritis Research UK Epidemiology Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J." last="Leo">Paul J. Leo</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Human Genetics Group</addr-line>,<institution>University of Queensland Diamantina Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="af25"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hwang, Joo Yeon" sort="Hwang, Joo Yeon" uniqKey="Hwang J" first="Joo-Yeon" last="Hwang">Joo-Yeon Hwang</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Center for Genome Science</addr-line>,<institution>National Institute of Health, Osong Health Technology Administration Complex</institution>,<addr-line>Chungcheongbuk-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ohlsson, Claes" sort="Ohlsson, Claes" uniqKey="Ohlsson C" first="Claes" last="Ohlsson">Claes Ohlsson</name><affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Centre for Bone and Arthritis Research, Institute of Medicine</addr-line>,<institution>Sahlgrenska Academy, University of Gothenburg</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguigan, Fiona" sort="Mcguigan, Fiona" uniqKey="Mcguigan F" first="Fiona" last="Mcguigan">Fiona Mcguigan</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences</addr-line></nlm:aff><wicri:noCountry code="subfield">Department of Clinical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><affiliation><nlm:aff wicri:cut=" and" id="af32"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit</addr-line>,<institution>University of Edinburgh</institution>,<addr-line>Edinburgh</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olmos, Jose M" sort="Olmos, Jose M" uniqKey="Olmos J" first="José M." last="Olmos">José M. Olmos</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af38"><addr-line>Department of Clinical Chemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lewis, Joshua R" sort="Lewis, Joshua R" uniqKey="Lewis J" first="Joshua R." last="Lewis">Joshua R. Lewis</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Swart, Karin M A" sort="Swart, Karin M A" uniqKey="Swart K" first="Karin M. A." last="Swart">Karin M. A. Swart</name><affiliation><nlm:aff id="af40"><addr-line>Department of Epidemiology and Biostatistics, the EMGO Institute of Health and Care Research</addr-line></nlm:aff><wicri:noCountry code="subfield">the EMGO Institute of Health and Care Research</wicri:noCountry></affiliation></author><author><name sortKey="Masi, Laura" sort="Masi, Laura" uniqKey="Masi L" first="Laura" last="Masi">Laura Masi</name><affiliation><nlm:aff wicri:cut=" and" id="af43"><addr-line>Metabolic Bone Diseases Unit – AOUC</addr-line></nlm:aff></affiliation></author><author><name sortKey="Oldmeadow, Chris" sort="Oldmeadow, Chris" uniqKey="Oldmeadow C" first="Chris" last="Oldmeadow">Chris Oldmeadow</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Sulin" sort="Cheng, Sulin" uniqKey="Cheng S" first="Sulin" last="Cheng">Sulin Cheng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>Department of Health Sciences</addr-line>,<institution>University of Jyväskylä</institution>,<addr-line>Jyväskylä</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Schoor, Natasja M" sort="Van Schoor, Natasja M" uniqKey="Van Schoor N" first="Natasja M." last="Van Schoor">Natasja M. Van Schoor</name><affiliation><nlm:aff id="af40"><addr-line>Department of Epidemiology and Biostatistics, the EMGO Institute of Health and Care Research</addr-line></nlm:aff><wicri:noCountry code="subfield">the EMGO Institute of Health and Care Research</wicri:noCountry></affiliation></author><author><name sortKey="Harvey, Nicholas C" sort="Harvey, Nicholas C" uniqKey="Harvey N" first="Nicholas C." last="Harvey">Nicholas C. Harvey</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kruk, Marcin" sort="Kruk, Marcin" uniqKey="Kruk M" first="Marcin" last="Kruk">Marcin Kruk</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Del Greco M, Fabiola" sort="Del Greco M, Fabiola" uniqKey="Del Greco M F" first="Fabiola" last="Del Greco M">Fabiola Del Greco M</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Center for Biomedicine</addr-line>,<institution>European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff wicri:cut=" and" id="af50"><addr-line>Department of Immunology, Genetics and Pathology, SciLifeLab</addr-line>,<institution>Rudbeck Laboratory</institution></nlm:aff></affiliation></author><author><name sortKey="Trummer, Olivia" sort="Trummer, Olivia" uniqKey="Trummer O" first="Olivia" last="Trummer">Olivia Trummer</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Internal Medicine, Division of Endocrinology and Metabolism</addr-line>,<institution>Medical University Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grigoriou, Efi" sort="Grigoriou, Efi" uniqKey="Grigoriou E" first="Efi" last="Grigoriou">Efi Grigoriou</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Department of Nutrition and Dietetics</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Yanhua" sort="Zhou, Yanhua" uniqKey="Zhou Y" first="Yanhua" last="Zhou">Yanhua Zhou</name><affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Department of Biostatistics</addr-line>,<institution>Boston University School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oei, Ling" sort="Oei, Ling" uniqKey="Oei L" first="Ling" last="Oei">Ling Oei</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zmuda, Joseph" sort="Zmuda, Joseph" uniqKey="Zmuda J" first="Joseph" last="Zmuda">Joseph Zmuda</name><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Department of Epidemiology, Graduate School of Public Health</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pitsburgh, PA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tranah, Greg" sort="Tranah, Greg" uniqKey="Tranah G" first="Greg" last="Tranah">Greg Tranah</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>San Francisco Coordinating Center, California Pacific Medical Center Research Institute</addr-line></nlm:aff><wicri:noCountry code="subfield">California Pacific Medical Center Research Institute</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Suzanne J" sort="Brown, Suzanne J" uniqKey="Brown S" first="Suzanne J." last="Brown">Suzanne J. Brown</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Frances M" sort="Williams, Frances M" uniqKey="Williams F" first="Frances M." last="Williams">Frances M. Williams</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="af57"><institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jakobsdottir, Johanna" sort="Jakobsdottir, Johanna" uniqKey="Jakobsdottir J" first="Johanna" last="Jakobsdottir">Johanna Jakobsdottir</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siggeirsdottir, Kristin" sort="Siggeirsdottir, Kristin" uniqKey="Siggeirsdottir K" first="Kristin" last="Siggeirsdottir">Kristin Siggeirsdottir</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Kate L" sort="Holliday, Kate L" uniqKey="Holliday K" first="Kate L." last="Holliday">Kate L. Holliday</name><affiliation><nlm:aff wicri:cut=", and" id="af22"><addr-line>Arthritis Research UK Epidemiology Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hannemann, Anke" sort="Hannemann, Anke" uniqKey="Hannemann A" first="Anke" last="Hannemann">Anke Hannemann</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Go, Min Jin" sort="Go, Min Jin" uniqKey="Go M" first="Min Jin" last="Go">Min Jin Go</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Center for Genome Science</addr-line>,<institution>National Institute of Health, Osong Health Technology Administration Complex</institution>,<addr-line>Chungcheongbuk-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Public Health, Medical School</addr-line>,<institution>University of Split</institution>,<addr-line>Split</addr-line>,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laaksonen, Marika" sort="Laaksonen, Marika" uniqKey="Laaksonen M" first="Marika" last="Laaksonen">Marika Laaksonen</name><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Department of Food and Environmental Sciences</addr-line>,<institution>University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Kun" sort="Zhu, Kun" uniqKey="Zhu K" first="Kun" last="Zhu">Kun Zhu</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enneman, Anke W" sort="Enneman, Anke W" uniqKey="Enneman A" first="Anke W." last="Enneman">Anke W. Enneman</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcevoy, Mark" sort="Mcevoy, Mark" uniqKey="Mcevoy M" first="Mark" last="Mcevoy">Mark Mcevoy</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peel, Roseanne" sort="Peel, Roseanne" uniqKey="Peel R" first="Roseanne" last="Peel">Roseanne Peel</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sham, Pak Chung" sort="Sham, Pak Chung" uniqKey="Sham P" first="Pak Chung" last="Sham">Pak Chung Sham</name><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Department of Psychiatry</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Centre for Reproduction, Development and Growth</addr-line>,<institution>The University of Hong Kong</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jaworski, Maciej" sort="Jaworski, Maciej" uniqKey="Jaworski M" first="Maciej" last="Jaworski">Maciej Jaworski</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff wicri:cut=" and" id="af50"><addr-line>Department of Immunology, Genetics and Pathology, SciLifeLab</addr-line>,<institution>Rudbeck Laboratory</institution></nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Center for Biomedicine</addr-line>,<institution>European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pludowski, Pawel" sort="Pludowski, Pawel" uniqKey="Pludowski P" first="Pawel" last="Pludowski">Pawel Pludowski</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dhonukshe Rutten, Rosalie A M" sort="Dhonukshe Rutten, Rosalie A M" uniqKey="Dhonukshe Rutten R" first="Rosalie A. M." last="Dhonukshe-Rutten">Rosalie A. M. Dhonukshe-Rutten</name><affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Human Nutrition</addr-line>,<institution>Wageningen University</institution>,<addr-line>Wageningen</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Velde, Nathalie" sort="Van Der Velde, Nathalie" uniqKey="Van Der Velde N" first="Nathalie" last="Van Der Velde">Nathalie Van Der Velde</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Department of Internal Medicine, Section of Geriatrics</addr-line>,<institution>Academic Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>Department of Clinical Physiology</addr-line>,<institution>University of Tampere School of Medicine</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Department of Clinical Physiology</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viikari, Jorma S" sort="Viikari, Jorma S" uniqKey="Viikari J" first="Jorma S." last="Viikari">Jorma S. Viikari</name><affiliation><nlm:aff wicri:cut=" and" id="af64"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af66"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Siev Nen, Harri" sort="Siev Nen, Harri" uniqKey="Siev Nen H" first="Harri" last="Siev Nen">Harri Siev Nen</name><affiliation wicri:level="1"><nlm:aff id="af68"><institution>The UKK Institute for Health Promotion Research</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="1"><nlm:aff id="af65"><addr-line>Department of Clinical Physiology and Nuclear Medicine</addr-line>,<institution>Turku University Hospital</institution>,<addr-line>Turku</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af67"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine</addr-line>,<institution>University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Macias, Jesus" sort="Gonzalez Macias, Jesus" uniqKey="Gonzalez Macias J" first="Jesús" last="González-Macías">Jesús González-Macías</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hernandez, Jose L" sort="Hernandez, Jose L" uniqKey="Hernandez J" first="Jose L." last="Hernández">Jose L. Hernández</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mellstrom, Dan" sort="Mellstrom, Dan" uniqKey="Mellstrom D" first="Dan" last="Mellström">Dan Mellström</name><affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Centre for Bone and Arthritis Research, Institute of Medicine</addr-line>,<institution>Sahlgrenska Academy, University of Gothenburg</institution>,<addr-line>Gothenburg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ljunggren, Osten" sort="Ljunggren, Osten" uniqKey="Ljunggren O" first="Östen" last="Ljunggren">Östen Ljunggren</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Department of Medical Sciences</addr-line>,<institution>University of Uppsala</institution>,<addr-line>Uppsala</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cho, Yoon Shin" sort="Cho, Yoon Shin" uniqKey="Cho Y" first="Yoon Shin" last="Cho">Yoon Shin Cho</name><affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>Department of Biomedical Science</addr-line>,<institution>Hallym University</institution>,<addr-line>Chuncheon, Gangwon-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="af25"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="af25"><addr-line>Interfaculty Institute for Genetics and Functional Genomics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>Institute for Community Medicine</addr-line>,<institution>University Medicine Greifswald</institution>,<institution>University of Greifswald</institution>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haring, Robin" sort="Haring, Robin" uniqKey="Haring R" first="Robin" last="Haring">Robin Haring</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A." last="Brown">Matthew A. Brown</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Human Genetics Group</addr-line>,<institution>University of Queensland Diamantina Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mccloskey, Eugene" sort="Mccloskey, Eugene" uniqKey="Mccloskey E" first="Eugene" last="Mccloskey">Eugene Mccloskey</name><affiliation><nlm:aff wicri:cut=" and" id="af70"><addr-line>National Institute for Health and Research (NIHR) Musculoskeletal Biomedical Research Unit</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af71"><addr-line>Academic Unit of Bone Metabolism</addr-line>,<institution>Metabolic Bone Centre</institution>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nicholson, Geoffrey C" sort="Nicholson, Geoffrey C" uniqKey="Nicholson G" first="Geoffrey C." last="Nicholson">Geoffrey C. Nicholson</name><affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Rural Clinical School</addr-line>,<institution>The University of Queensland</institution>,<addr-line>Toowoomba</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eastell, Richard" sort="Eastell, Richard" uniqKey="Eastell R" first="Richard" last="Eastell">Richard Eastell</name><affiliation wicri:level="1"><nlm:aff id="af71"><addr-line>Academic Unit of Bone Metabolism</addr-line>,<institution>Metabolic Bone Centre</institution>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eisman, John A" sort="Eisman, John A" uniqKey="Eisman J" first="John A." last="Eisman">John A. Eisman</name><affiliation wicri:level="1"><nlm:aff id="af73"><addr-line>Clinical Translation and Advanced Education and Osteoporosis and Bone Biology Program</addr-line>,<institution>Garvan Institute of Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Department of Medicine</addr-line>,<institution>University of New South Wales</institution>,<addr-line>Kensington</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Clinical Excellence and Research, School of Medicine Sydney</addr-line>,<institution>University of Notre Dame</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Department of Endocrinology</addr-line>,<institution>St Vincent's Hospital</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Graeme" sort="Jones, Graeme" uniqKey="Jones G" first="Graeme" last="Jones">Graeme Jones</name><affiliation wicri:level="1"><nlm:aff id="af77"><institution>Menzies Research Institute</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reid, Ian R" sort="Reid, Ian R" uniqKey="Reid I" first="Ian R." last="Reid">Ian R. Reid</name><affiliation wicri:level="1"><nlm:aff id="af78"><addr-line>Department of Medicine</addr-line>,<institution>University of Auckland</institution>,<addr-line>Auckland</addr-line>,<country>New Zealand</country></nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dennison, Elaine M" sort="Dennison, Elaine M" uniqKey="Dennison E" first="Elaine M." last="Dennison">Elaine M. Dennison</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wark, John" sort="Wark, John" uniqKey="Wark J" first="John" last="Wark">John Wark</name><affiliation wicri:level="1"><nlm:aff id="af79"><addr-line>Department of Clinical Sciences</addr-line>,<institution>Royal Melbourne Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><nlm:aff wicri:cut=" and" id="af80"><addr-line>Leuven University Division of Geriatric Medicine and Centre for Metabolic Bone Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vanderschueren, Dirk" sort="Vanderschueren, Dirk" uniqKey="Vanderschueren D" first="Dirk" last="Vanderschueren">Dirk Vanderschueren</name><affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Department of Andrology and Endocrinology</addr-line>,<institution>Katholieke Universiteit Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Frederick C W" sort="Wu, Frederick C W" uniqKey="Wu F" first="Frederick C. W." last="Wu">Frederick C. W. Wu</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Andrology Research Unit, Developmental & Regenerative Biomedicine Research Group</addr-line>,<institution>The University of Manchester</institution>,<institution>Manchester Academic Health Science Centre, Manchester Royal Infirmary</institution>,<addr-line>Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, J Brent" sort="Richards, J Brent" uniqKey="Richards J" first="J. Brent" last="Richards">J. Brent Richards</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Departments of Medicine, Human Genetics, Epidemiology and Biostatistics</addr-line>,<institution>Lady Davis Institute</institution>,<institution>McGill University</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bauer, Doug" sort="Bauer, Doug" uniqKey="Bauer D" first="Doug" last="Bauer">Doug Bauer</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>San Francisco Coordinating Center, California Pacific Medical Center Research Institute</addr-line></nlm:aff><wicri:noCountry code="subfield">California Pacific Medical Center Research Institute</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Department of Nutrition and Dietetics</addr-line>,<institution>Harokopio University</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Obermayer Pietsch, Barbara" sort="Obermayer Pietsch, Barbara" uniqKey="Obermayer Pietsch B" first="Barbara" last="Obermayer-Pietsch">Barbara Obermayer-Pietsch</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Internal Medicine, Division of Endocrinology and Metabolism</addr-line>,<institution>Medical University Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff wicri:cut=" and" id="af50"><addr-line>Department of Immunology, Genetics and Pathology, SciLifeLab</addr-line>,<institution>Rudbeck Laboratory</institution></nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Center for Biomedicine</addr-line>,<institution>European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lorenc, Roman S" sort="Lorenc, Roman S" uniqKey="Lorenc R" first="Roman S." last="Lorenc">Roman S. Lorenc</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Department of Biochemistry, Radioimmunology & Experimental Medicine</addr-line>,<institution>The Children's Memorial Health Institute</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>MRC Lifecourse Epidemiology Unit</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>NIHR Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Science</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kung, Annie Wai Chee" sort="Kung, Annie Wai Chee" uniqKey="Kung A" first="Annie Wai Chee" last="Kung">Annie Wai Chee Kung</name><affiliation><nlm:aff id="af10"><addr-line>Department of Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Research Centre of Heart, Brain, Hormone & Healthy Aging</addr-line></nlm:aff><wicri:noCountry code="subfield">Hormone & Healthy Aging</wicri:noCountry></affiliation></author><author><name sortKey="Lips, Paul" sort="Lips, Paul" uniqKey="Lips P" first="Paul" last="Lips">Paul Lips</name><affiliation><nlm:aff wicri:cut=" and" id="af41"><addr-line>Department of Endocrinology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af42"><addr-line>EMGO Institute for Health and Care Research</addr-line>,<institution>VU University Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alen, Markku" sort="Alen, Markku" uniqKey="Alen M" first="Markku" last="Alen">Markku Alen</name><affiliation wicri:level="1"><nlm:aff id="af83"><addr-line>Department of Medical Rehabilitation</addr-line>,<institution>Oulu University Hospital and Institute of Health Sciences</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:aff id="af45"><institution>University of Newcastle and Hunter Medical Research Institute</institution>,<institution>John Hunter Hospital</institution>,<addr-line>Newcastle, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name><affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Surgery and Translational Medicine</addr-line>,<institution>University of Florence</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Groot, Lisette C P G M" sort="De Groot, Lisette C P G M" uniqKey="De Groot L" first="Lisette C. P. G. M." last="De Groot">Lisette C. P. G. M. De Groot</name><affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Human Nutrition</addr-line>,<institution>Wageningen University</institution>,<addr-line>Wageningen</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Clinical Chemistry</addr-line>,<institution>Fimlab Laboratories</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af38"><addr-line>Department of Clinical Chemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Riancho, Jose A" sort="Riancho, Jose A" uniqKey="Riancho J" first="José A." last="Riancho">José A. Riancho</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>University of Cantabria</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Department of Internal Medicine</addr-line>,<institution>Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV)</institution>,<addr-line>Santander</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="af84"><institution>Centre for Population Health Sciences, Medical School</institution>,<addr-line>Teviot Place, Edinburgh</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="af85"><addr-line>Center for Human Genetics, Division of Public Health Sciences</addr-line>,<institution>Wake Forest School of Medicine</institution>,<addr-line>Winston-Salem, NC</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>,<institution>National Institute on Aging</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akesson, Kristina" sort="Akesson, Kristina" uniqKey="Akesson K" first="Kristina" last="Akesson">Kristina Akesson</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences</addr-line></nlm:aff><wicri:noCountry code="subfield">Department of Clinical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Karlsson, Magnus" sort="Karlsson, Magnus" uniqKey="Karlsson M" first="Magnus" last="Karlsson">Magnus Karlsson</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences</addr-line></nlm:aff><wicri:noCountry code="subfield">Department of Clinical Sciences</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Orthopaedics</addr-line>,<institution>Lund University</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Jong Young" sort="Lee, Jong Young" uniqKey="Lee J" first="Jong-Young" last="Lee">Jong-Young Lee</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Center for Genome Science</addr-line>,<institution>National Institute of Health, Osong Health Technology Administration Complex</institution>,<addr-line>Chungcheongbuk-do</addr-line>,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff wicri:cut=" and" id="af26"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duncan, Emma L" sort="Duncan, Emma L" uniqKey="Duncan E" first="Emma L." last="Duncan">Emma L. Duncan</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Human Genetics Group</addr-line>,<institution>University of Queensland Diamantina Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Endocrinology</addr-line>,<institution>Royal Brisbane and Women's Hospital</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Neill, Terence W" sort="O Neill, Terence W" uniqKey="O Neill T" first="Terence W." last="O'Neill">Terence W. O'Neill</name><affiliation><nlm:aff wicri:cut=", and" id="af22"><addr-line>Arthritis Research UK Epidemiology Unit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="af20"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Iceland</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Twin Research and Genetic Epidemiology</addr-line>,<institution>King's College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rousseau, Francois" sort="Rousseau, Francois" uniqKey="Rousseau F" first="François" last="Rousseau">François Rousseau</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>Centre de Récherche du CHU de Québec/HSFA</institution>,<addr-line>Québec City</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af87"><addr-line>Department of Molecular Biology, Medical Biochemistry and Pathology</addr-line></nlm:aff><wicri:noCountry code="subfield">Medical Biochemistry and Pathology</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af88"><addr-line>The APOGEE-Net/CanGèneTest Network on Genetic Health Services and Policy</addr-line>,<institution>Université Laval</institution>,<addr-line>Québec City</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Orwoll, Eric" sort="Orwoll, Eric" uniqKey="Orwoll E" first="Eric" last="Orwoll">Eric Orwoll</name><affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>School of Medicine</addr-line>,<institution>Oregon Health & Science University</institution>,<addr-line>Portland, OR</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cummings, Steven R" sort="Cummings, Steven R" uniqKey="Cummings S" first="Steven R." last="Cummings">Steven R. Cummings</name><affiliation><nlm:aff wicri:cut=" and" id="af55"><addr-line>San Francisco Coordinating Center, California Pacific Medical Center Research Institute</addr-line></nlm:aff><wicri:noCountry code="subfield">California Pacific Medical Center Research Institute</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af89"><addr-line>MRC Epidemiology Unit</addr-line>,<institution>Institute of Metabolic Science</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Epidemiology</addr-line>,<addr-line>Erasmus Medical Center Rotterdam, Rotterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prince, Richard L" sort="Prince, Richard L" uniqKey="Prince R" first="Richard L." last="Prince">Richard L. Prince</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>School of Medicine and Pharmacology</addr-line>,<institution>University of Western Australia</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Endocrinology and Diabetes</addr-line>,<institution>Sir Charles Gairdner Hospital</institution>,<addr-line>Perth</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P." last="Kiel">Douglas P. Kiel</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institute for Aging Research</addr-line>,<institution>Hebrew SeniorLife</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Medicine</addr-line>,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reeve, Jonathan" sort="Reeve, Jonathan" uniqKey="Reeve J" first="Jonathan" last="Reeve">Jonathan Reeve</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>NIHR Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Science</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af90"><institution>Strangeways Research Laboratory</institution>,<addr-line>Worts’ Causeway, Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaptoge, Stephen K" sort="Kaptoge, Stephen K" uniqKey="Kaptoge S" first="Stephen K." last="Kaptoge">Stephen K. Kaptoge</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af90"><institution>Strangeways Research Laboratory</institution>,<addr-line>Worts’ Causeway, Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; <italic>n</italic> = 14 260), velocity of sound (VOS; <italic>n</italic> = 15 514) and BMD (<italic>n</italic> = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (<italic>in silico n</italic> = 11 452) and new genotyping in 15 cohorts (<italic>de novo n</italic> = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (<italic>P</italic> < 5 × 10<sup>−8</sup>) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including <italic>ESR1</italic> (6q25.1: rs4869739, rs3020331, rs2982552), <italic>SPTBN1</italic> (2p16.2: rs11898505), <italic>RSPO3</italic> (6q22.33: rs7741021), <italic>WNT16</italic> (7q31.31: rs2908007), <italic>DKK1</italic> (10q21.1: rs7902708) and <italic>GPATCH1</italic> (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to <italic>TMEM135</italic>, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (<italic>P</italic> < 8.23 × 10<sup>−14</sup>). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at <italic>P</italic> < 5 × 10<sup>−6</sup> also had the expected direction of association with any fracture (<italic>P</italic> < 0.05), including three SNPs with <italic>P</italic> < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Corée du Sud</li><li>Croatie</li><li>Espagne</li><li>Finlande</li><li>Grèce</li><li>Islande</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suède</li><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Boston</li></settlement></list><tree><noCountry><name sortKey="Akesson, Kristina" sort="Akesson, Kristina" uniqKey="Akesson K" first="Kristina" last="Akesson">Kristina Akesson</name><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><name sortKey="Enneman, Anke W" sort="Enneman, Anke W" uniqKey="Enneman A" first="Anke W." last="Enneman">Anke W. Enneman</name><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><name sortKey="Hannemann, Anke" sort="Hannemann, Anke" uniqKey="Hannemann A" first="Anke" last="Hannemann">Anke Hannemann</name><name sortKey="Haring, Robin" sort="Haring, Robin" uniqKey="Haring R" first="Robin" last="Haring">Robin Haring</name><name sortKey="Holliday, Kate L" sort="Holliday, Kate L" uniqKey="Holliday K" first="Kate L." last="Holliday">Kate L. Holliday</name><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><name sortKey="Kung, Annie Wai Chee" sort="Kung, Annie Wai Chee" uniqKey="Kung A" first="Annie Wai Chee" last="Kung">Annie Wai Chee Kung</name><name sortKey="Masi, Laura" sort="Masi, Laura" uniqKey="Masi L" first="Laura" last="Masi">Laura Masi</name><name sortKey="Mcguigan, Fiona" sort="Mcguigan, Fiona" uniqKey="Mcguigan F" first="Fiona" last="Mcguigan">Fiona Mcguigan</name><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><name sortKey="Nielson, Carrie" sort="Nielson, Carrie" uniqKey="Nielson C" first="Carrie" last="Nielson">Carrie Nielson</name><name sortKey="O Neill, Terence W" sort="O Neill, Terence W" uniqKey="O Neill T" first="Terence W." last="O'Neill">Terence W. O'Neill</name><name sortKey="Pye, Stephen R" sort="Pye, Stephen R" uniqKey="Pye S" first="Stephen R." last="Pye">Stephen R. Pye</name><name sortKey="Srikanth, Priya" sort="Srikanth, Priya" uniqKey="Srikanth P" first="Priya" last="Srikanth">Priya Srikanth</name><name sortKey="Swart, Karin M A" sort="Swart, Karin M A" uniqKey="Swart K" first="Karin M. A." last="Swart">Karin M. A. Swart</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><name sortKey="Van Schoor, Natasja M" sort="Van Schoor, Natasja M" uniqKey="Van Schoor N" first="Natasja M." last="Van Schoor">Natasja M. Van Schoor</name><name sortKey="Viikari, Jorma S" sort="Viikari, Jorma S" uniqKey="Viikari J" first="Jorma S." last="Viikari">Jorma S. Viikari</name><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><name sortKey="Xiao, Su Mei" sort="Xiao, Su Mei" uniqKey="Xiao S" first="Su-Mei" last="Xiao">Su-Mei Xiao</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name></noRegion><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Dennison, Elaine M" sort="Dennison, Elaine M" uniqKey="Dennison E" first="Elaine M." last="Dennison">Elaine M. Dennison</name><name sortKey="Eastell, Richard" sort="Eastell, Richard" uniqKey="Eastell R" first="Richard" last="Eastell">Richard Eastell</name><name sortKey="Harvey, Nicholas C" sort="Harvey, Nicholas C" uniqKey="Harvey N" first="Nicholas C." last="Harvey">Nicholas C. Harvey</name><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><name sortKey="Kaptoge, Stephen K" sort="Kaptoge, Stephen K" uniqKey="Kaptoge S" first="Stephen K." last="Kaptoge">Stephen K. Kaptoge</name><name sortKey="Kaptoge, Stephen K" sort="Kaptoge, Stephen K" uniqKey="Kaptoge S" first="Stephen K." last="Kaptoge">Stephen K. Kaptoge</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><name sortKey="Mccloskey, Eugene" sort="Mccloskey, Eugene" uniqKey="Mccloskey E" first="Eugene" last="Mccloskey">Eugene Mccloskey</name><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><name sortKey="Reeve, Jonathan" sort="Reeve, Jonathan" uniqKey="Reeve J" first="Jonathan" last="Reeve">Jonathan Reeve</name><name sortKey="Reeve, Jonathan" sort="Reeve, Jonathan" uniqKey="Reeve J" first="Jonathan" last="Reeve">Jonathan Reeve</name><name sortKey="Reeve, Jonathan" sort="Reeve, Jonathan" uniqKey="Reeve J" first="Jonathan" last="Reeve">Jonathan Reeve</name><name sortKey="Richards, J Brent" sort="Richards, J Brent" uniqKey="Richards J" first="J. Brent" last="Richards">J. Brent Richards</name><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><name sortKey="Williams, Frances M" sort="Williams, Frances M" uniqKey="Williams F" first="Frances M." last="Williams">Frances M. Williams</name><name sortKey="Wilson, Scott G" sort="Wilson, Scott G" uniqKey="Wilson S" first="Scott G." last="Wilson">Scott G. Wilson</name><name sortKey="Wu, Frederick C W" sort="Wu, Frederick C W" uniqKey="Wu F" first="Frederick C. W." last="Wu">Frederick C. W. Wu</name></country><country name="États-Unis"><noRegion><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name></noRegion><name sortKey="Bauer, Doug" sort="Bauer, Doug" uniqKey="Bauer D" first="Doug" last="Bauer">Doug Bauer</name><name sortKey="Cummings, Steven R" sort="Cummings, Steven R" uniqKey="Cummings S" first="Steven R." last="Cummings">Steven R. Cummings</name><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P." last="Kiel">Douglas P. Kiel</name><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P." last="Kiel">Douglas P. Kiel</name><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><name sortKey="Orwoll, Eric" sort="Orwoll, Eric" uniqKey="Orwoll E" first="Eric" last="Orwoll">Eric Orwoll</name><name sortKey="Tranah, Greg" sort="Tranah, Greg" uniqKey="Tranah G" first="Greg" last="Tranah">Greg Tranah</name><name sortKey="Zhou, Yanhua" sort="Zhou, Yanhua" uniqKey="Zhou Y" first="Yanhua" last="Zhou">Yanhua Zhou</name><name sortKey="Zmuda, Joseph" sort="Zmuda, Joseph" uniqKey="Zmuda J" first="Joseph" last="Zmuda">Joseph Zmuda</name></country><country name="Pays-Bas"><noRegion><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name></noRegion><name sortKey="De Groot, Lisette C P G M" sort="De Groot, Lisette C P G M" uniqKey="De Groot L" first="Lisette C. P. G. M." last="De Groot">Lisette C. P. G. M. De Groot</name><name sortKey="Dhonukshe Rutten, Rosalie A M" sort="Dhonukshe Rutten, Rosalie A M" uniqKey="Dhonukshe Rutten R" first="Rosalie A. M." last="Dhonukshe-Rutten">Rosalie A. M. Dhonukshe-Rutten</name><name sortKey="Estrada, Karol" sort="Estrada, Karol" uniqKey="Estrada K" first="Karol" last="Estrada">Karol Estrada</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Lips, Paul" sort="Lips, Paul" uniqKey="Lips P" first="Paul" last="Lips">Paul Lips</name><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><name sortKey="Medina Gomez, Carolina" sort="Medina Gomez, Carolina" uniqKey="Medina Gomez C" first="Carolina" last="Medina-Gomez">Carolina Medina-Gomez</name><name sortKey="Oei, Ling" sort="Oei, Ling" uniqKey="Oei L" first="Ling" last="Oei">Ling Oei</name><name sortKey="Oei, Ling" sort="Oei, Ling" uniqKey="Oei L" first="Ling" last="Oei">Ling Oei</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Van Der Velde, Nathalie" sort="Van Der Velde, Nathalie" uniqKey="Van Der Velde N" first="Nathalie" last="Van Der Velde">Nathalie Van Der Velde</name></country><country name="Canada"><noRegion><name sortKey="Giroux, Sylvie" sort="Giroux, Sylvie" uniqKey="Giroux S" first="Sylvie" last="Giroux">Sylvie Giroux</name></noRegion><name sortKey="Richards, J Brent" sort="Richards, J Brent" uniqKey="Richards J" first="J. Brent" last="Richards">J. 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Raitakari</name><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><name sortKey="Siev Nen, Harri" sort="Siev Nen, Harri" uniqKey="Siev Nen H" first="Harri" last="Siev Nen">Harri Siev Nen</name></country><country name="Pologne"><noRegion><name sortKey="Kruk, Marcin" sort="Kruk, Marcin" uniqKey="Kruk M" first="Marcin" last="Kruk">Marcin Kruk</name></noRegion><name sortKey="Jaworski, Maciej" sort="Jaworski, Maciej" uniqKey="Jaworski M" first="Maciej" last="Jaworski">Maciej Jaworski</name><name sortKey="Lorenc, Roman S" sort="Lorenc, Roman S" uniqKey="Lorenc R" first="Roman S." last="Lorenc">Roman S. 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Pramstaller</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name></country><country name="Autriche"><noRegion><name sortKey="Trummer, Olivia" sort="Trummer, Olivia" uniqKey="Trummer O" first="Olivia" last="Trummer">Olivia Trummer</name></noRegion><name sortKey="Obermayer Pietsch, Barbara" sort="Obermayer Pietsch, Barbara" uniqKey="Obermayer Pietsch B" first="Barbara" last="Obermayer-Pietsch">Barbara Obermayer-Pietsch</name></country><country name="Grèce"><noRegion><name sortKey="Grigoriou, Efi" sort="Grigoriou, Efi" uniqKey="Grigoriou E" first="Efi" last="Grigoriou">Efi Grigoriou</name></noRegion><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name></country><country name="Croatie"><noRegion><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Sham, Pak Chung" sort="Sham, Pak Chung" uniqKey="Sham P" first="Pak Chung" last="Sham">Pak Chung Sham</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Reid, Ian R" sort="Reid, Ian R" uniqKey="Reid I" first="Ian R." last="Reid">Ian R. Reid</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Vanderschueren, Dirk" sort="Vanderschueren, Dirk" uniqKey="Vanderschueren D" first="Dirk" last="Vanderschueren">Dirk Vanderschueren</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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